Determination of Deformable Image Registration Algorithms for Accumulating Dose in Carbon-ion Radiotherapy for Pancreatic Cancer

Background/Aim: This study aimed to determine appropriate deformable image registration (DIR) algorithms for pancreatic cancer patients undergoing carbon ion radiotherapy (CIRT). Patients and Methods: The performance of three types DIR algorithms, including intensity-based (iDIR), contour-based (cDIR), hybrid (hDIR) were evaluated using seventy-one CT images from eight patients. Both the geometry CTV subsequent dose warping discrepancies dice similarity coefficient (DSC) difference in V95. Results: cDIR hDIR had superior than iDIR both DSC V95 (p<0.0001). caused accumulated be underestimated by 5% median compared other methods. Conclusion: can utilized assess CIRT cancer. considered when obtained is greater 0.89.